BRAIN Funded Research 2021

Using a Humanized Mouse Model And Human Intestinal Tissue to Evaluate the Zonulin Pathway For Personalized Treatment of Autism

PROJECT PI: Dr Alessio Fasano, Professor of Pediatrics & Vice Chair of Research at Mass. General Hospital, Professor of Nutrition at Harvard T.H. Chan School of Public Health.
PROJECT FOCUS: gut permeability/microbiome /immune response interplay in autism
PROJECT AIMS: advance our understanding of ASD pathogenesis and the mechanisms behind increased gut permeability; identify biomarkers to stratify the ASD population in specific subgroups; validate the zonulin inhibitor AT1001 (already showing robust safety profiles in phase 3 human trials with the name Larazotide acetate) as a possible personalized therapeutic strategic treatment, so posing foundations for future clinical trials in ASD.

Evaluation of Transcranial Photobiomodulation in Autism: Double-Blind, Placebo-Controlled, Randomized Study

PROJECT PI: Tolga Atilla Ceranoglu, MD, Assistant Professor in Psychiatry, Harvard Medical School and Mass. General Hospital.
PROJECT FOCUS: transcranial photobiomodulation (t-PBM) is a novel form of neuromodulation that is based on non-retinal exposure to light at specific wavelengths. So far it has yielded very promising early results for the treatment of several neuropsychiatric disorders. Its mechanisms of action include increasing mitochondrial energy production, lowering inflammation and increasing regional blood flow in the brain. The treatment has a low cost, good safety profile, and it is easy to self-administer.
PROJECT AIMS: evaluate efficacy and safety of t-PBM treatment of autism and provide the first step towards FDA approval.

Immunoregulation and Gastrointestinal Issues in Autism Spectrum Disorder

PROJECT PI: Paul Ashwood, PhD, Professor of Microbiology and Immunology, MIND Institute, University of California Davis.
PROJECT FOCUS: understand underlying pathological pathways in gastrointestinal (GI) issues in autism and develop treatment strategies.
PROJECT AIMS: determine the mechanisms of increased innate immune activation. The project will examine the hypothesis is that macrophage dysfunction in autism is due to epigenetic changes that cause increased immune activation, decreased endotoxin/bacterial tolerance, and lead to inflammation. The researchers will aim to identify a panel of biomarkers, or biological signatures, that could be used for patient stratification, development of new therapeutic targets, or to monitor treatment responses.

High-Frequency Oscillation as a Biomarker of Mitochondrial Dysfunction Associated with Epilepsy in Autism

PROJECT PI: Richard Frye, MD PhD, Pediatric Neurologist, Phoenix Children’s Hospital.
PROJECT FOCUS: studying mitochondrial dysfunction as a cause of epilepsy in individuals with and without autism as well as the correlation with these areas of mitochondrial dysfunction with high frequency oscillations (HFO) that can be recorded non-invasively as a biomarker of mitochondrial associated epilepsy. Individuals with autism are at an increased risk for epilepsy and seizures. Epilepsy is the leading cause of death in autism.
PROJECT AIMS: deepen our understanding of the biological mechanisms that underlie epilepsy, including treatment-resistant epilepsy, and to open a path to novel biomarkers, assessment methods and treatments.

Autism with Neurodevelopmental Regression Associated Mitochondrial Dysfunction: Further Development of In Vitro Models and Pathways to Treatment

PROJECT PI: Richard Frye, MD PhD, Pediatric Neurologist, Phoenix Children’s Hospital.
PROJECT FOCUS: mitochondrial dysfunction in regressive autism. About one-third of children with autism spectrum disorder demonstrate a major neurodevelopmental regression – loss of previously acquired language and social interaction skills, as well as emergence of restricted and repetitive behaviors.
PROJECT AIMS: The overall goal of this study is to develop better treatments for children with autism. In order to reach this aim, the investigators will further characterize mitochondrial dysfunction in their in vitro models and test agents that potentially modulate mitochondrial function in order to discover novel targeted treatments for this subset of autism.

Early Biomarkers in Autism Spectrum Disorders: Birth Folate Autoantibody Receptor Status

PROJECT PI: Harris Huberman, MD, Pediatrician, SUNY Downstate Medical Center.
PROJECT FOCUS: examine the role of folate receptor auto-antibodies (FRAA) in the development and manifestations of autism. Folate in the central nervous system plays a role in a myriad of metabolic, genomic and brain architectonic processes. FRAAs have been clearly correlated with autism and appear to constitute a significant contributing factor.
PROJECT AIMS: improve understanding of central folate deficiency on infant development; improve understanding how measures of brain activity and social behavior correlate with FRAA status, and later ASD diagnosis; improve early identification of ASD and lay the groundwork for future treatment interventions of high-risk infants with leucovorin.

Biomarkers of Innate Immune Memory in Autism Spectrum Disorders

PROJECT PI: Harumi Jyonouchi, MD, Board-certified Allergist/Immunologist, Saint Peter’s Hospital, Professor of Pediatrics at Rutgers Robert Wood Johnson Medical School.
PROJECT FOCUS: immune mediated inflammation that affects not only the brain but also other organs has been implicated in many of the observed clinical features in autism. However, inflammation in autism appears not associated with specific environmental factors, but appears to be driven by innate immune memory (IIM) responses that are generated by metabolic and epigenetic changes triggered by an initial stimulus.
PROJECT AIMS: determine the underlying mechanisms of immune mediated inflammation and their effects on the development and progress of autism.

Connecting Rare Genetic Mutations in Autism to Common Biological Pathways

PROJECT PI: Joseph D. Buxbaum, PhD, Professor of Psychiatry, Genetics and Neuroscience, Icahn School of Medicine at Mount Sinai. Director of the Seaver Autism Center.
PROJECT FOCUS: study the function of many autism-linked genes simultaneously, in order to identifying a smaller number of common pathways shared by those genes. Apply a computational drug repurposing approach to search for already existing compounds that would be predicted to revert altered ASD pathways to a healthy state.
PROJECT AIMS: improve our understand of how changes in nerve and brain development lead to autism disorder in order to develop effective new treatments for ASD we need to

Using AI & Machine Learning to Develop Metabolic Biomarkers in Autism Spectrum Disorders

PROJECT PI: Dr. Juergen Hahn, Professor & Department Head, Biomedical Engineering, Rensselaer Polytechnic Institute.
PROJECT FOCUS: analyzing measurements of metabolite concentrations of the folate-dependent one-carbon metabolism and transsulfuration pathways to distinguish children diagnosed with autism from their typically-developing peers.
PROJECT AIMS: replicate the results on a new, large cohort of children using state-of-the-art technologies appropriate for a commercial lab test; develop the foundation for autism biomarkers to be used for diagnosing autism and for assessing efficacy of treatments.

Study the Pathological Status in Gastrointestinal Tissue in GI Symptomatic Children with and without Autism

PROJECT PI: Stephen Walker, PhD, Professor of Regenerative Medicine, Wake Forest School of Medicine, and Arthur Krigsman MD, Board-certified Pediatric Gastroenterologist
PROJECT FOCUS: significant molecular pathology is often lurking in the normal or near normal light microscopic images of intestinal biopsy tissue of GI symptomatic children with ASD.
PROJECT AIMS: replicate the existing findings in order to provide support for a change in prevailing clinical practice of the evaluation of GI symptomatic ASD children to include a more thorough evaluation of biopsy tissue when the presenting symptoms are suggestive of an inflammatory phenotype.

MEF2C Haploinsufficiency Drug Discovery - Potential to Improve ASD Phenotypes

PROJECT PI: Stuart Lipton, MD, PhD, Professor of Molecular Medicine, Scripps Research.
PROJECT FOCUS: partial loss of MEF2C activity is known to lead to ASD, intellectual disability, epilepsy and other neurological symptoms. Since MEF2C is a major regulator of the expression of various other proteins known to be involved in various forms of ASD, such a drug may be an effective treatment for a wide variety of ASDs.
PROJECT AIMS: optimize lead compounds discovered by Lipton’s lab in order to develop drug candidates to treat a specific type of autism by increasing the activity of MEF2C neuronal transcription factor.

Pharmacologically Remediable Traits of ASD in a Mouse Model Implicate a Serotonin – Neuroinflammatory Connection

PROJECT PI: Randy Blakely, PhD, Professor of Biomedical Science, Florida Atlantic University.
PROJECT FOCUS:
PROJECT AIMS:

BRAIN Funded Research 2020

Characterizing Altered Innate Immune Memory in Autism & Exploring Select MicroRNAs as Biomarkers

PROJECT PI: Harumi Jyonouchi, MD, Board-certified Allergist/Immunologist, Saint Peter’s Hospital. Professor of Pediatrics, Rutgers Robert Wood Johnson Medical School.

Understanding Differences in Intestinal Epithelium in Autism and Controls & Constructing a Biobank of Intestinal Organoids

PROJECT PI: Paul Ashwood, PhD, Professor of Microbiology and Immunology at the MIND Institute, University of California Davis.

Microbiota Transfer Therapy for Individuals with Autism Spectrum Disorder, with Extensive Testing

PROJECT PI: James Adams, PhD, President’s Professor, Arizona State University.

Gene-Microbiome Interactions in ASD: the Effects on Neurotransmitter Release, Immune Responses & GI Function

PROJECT PI: Sarkis Mazmanian PhD, Luis & Nelly Soux Professor of Microbiology in the Division of Biology & Biological Engineering, Caltech.

Investigating Chemical Exposures and Crosstalk between the Metabolome and Exposome in Autism

PROJECT PI: Robert Naviaux, MD, PhD, UC San Diego

Explore if Treatments Targeting Mitochondrial Function in Autism Will Improve the Core Symptoms

PROJECT PI: Richard Frye, MD PhD, Pediatric Neurologist, Phoenix Children’s Hospital.

 

Establish a Rat Model of ASD to Study Genetic & Epigenetic Changes and Associated Behavioural Deficits

PROJECT PI: Edward Quadros, PhD, SUNY Downstate.

Symptom Improvement ASD Children Following Treatment for their Chronic GI Inflammation

PROJECT PI: Arthur Krigsman, MD, Board-certified Pediatric Gastroenterologist.

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