Scientific journal publications from research supported by The BRAIN Foundation

BRAIN funded/co-funded research publications

Ashwood P. Preliminary Findings of Elevated Inflammatory Plasma Cytokines in Children with Autism Who Have Co-Morbid Gastrointestinal Symptoms. Biomedicines. 2023 Feb 2;11(2):436. doi: 10.3390/biomedicines11020436. PMID: 36830973; PMCID: PMC9952966.

Bobrowski-Khoury N, Ramaekers VT, Sequeira JM, Quadros EV. Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorders: Diagnosis, Treatment and Prevention. J Pers Med. 2021 Jul 24;11(8):710. doi: 10.3390/jpm11080710. PMID: 34442354; PMCID: PMC8398778.

Bobrowski-Khoury N, Sequeira JM, Quadros EV. Brain Uptake of Folate Forms in the Presence of Folate Receptor Alpha Antibodies in Young Rats: Folate and Antibody Distribution. Nutrients. 2023 Feb 25;15(5):1167. doi: 10.3390/nu15051167. PMID: 36904166; PMCID: PMC10005127.

Brister D, Rose S, Delhey L, Tippett M, Jin Y, Gu H, Frye RE. Metabolomic Signatures of Autism Spectrum Disorder. J Pers Med. 2022 Oct 17;12(10):1727. doi: 10.3390/jpm12101727. PMID: 36294866; PMCID: PMC9604590.

Frye RE, Lane A, Worner A, Werner BA, McCarty PJ, Scheck AC, Collins HL, Adelman SJ, Quadros EV, Rossignol DA. The Soluble Folate Receptor in Autism Spectrum Disorder: Relation to Autism Severity and Leucovorin Treatment. J Pers Med. 2022 Dec 8;12(12):2033. doi: 10.3390/jpm12122033. PMID: 36556254; PMCID: PMC9786140.

Hughes HK, Rowland ME, Onore CE, Rogers S, Ciernia AV, Ashwood P. Dysregulated gene expression associated with inflammatory and translation pathways in activated monocytes from children with autism spectrum disorder. Transl Psychiatry. 2022 Jan 26;12(1):39. doi: 10.1038/s41398-021-01766-0. PMID: 35082275; PMCID: PMC8791942.

Jyonouchi H. Autism spectrum disorder and a possible role of anti-inflammatory treatments: experience in the pediatric allergy/immunology clinic. Front Psychiatry. 2024 Jun 24;15:1333717. doi: 10.3389/fpsyt.2024.1333717. PMID: 38979496; PMCID: PMC11228311.

Jyonouchi H. Inborn errors of immunity present with neuropsychiatric symptoms overlapping with autistic behavioral symptoms. J Transl Genet Genom. 2023 Dec 22;7:274-90. doi: 10.20517/jtgg.2023.32

Jyonouchi H, Geng L, Rossignol DA, Frye RE. Long COVID Syndrome Presenting as Neuropsychiatric Exacerbations in Autism Spectrum Disorder: Insights for Treatment. J Pers Med. 2022 Nov 2;12(11):1815. doi: 10.3390/jpm12111815. PMID: 36579544; PMCID: PMC9695881.

Jyonouchi H. Puzzling Presentation of Inborn Errors of Immunity (IEIs) with Predominant Neuropsychiatric Symptoms – Experience in the Pediatric Allergy/Immunology Clinic. J Clin Cell Immunol. 2024;15:709. Doi: 10.35248/2155-9899.24.16.747

Knopp J, Weaver A, Miller S, Nomura T, Whitlark A, Swantkowski J, Noble A, Nam S, Hutson K, BergqvistPatzke J, Contractor A, Patzke C. Human and mouse models for Kabuki syndrome reveal increase in inhibitory synapse development. bioRxiv. 2024 Oct 5;2024.10.04.616529. doi: 10.1101/2024.10.04.616738 [PREPRINT]

Lingampelly SS, Naviaux JC, Heuer LS, Monk JM, Li K, Wang L, Haapanen L, Kelland CA, Van de Water J, Naviaux RK. Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder. Commun Biol. 2024 May 10;7(1):536. doi: 10.1038/s42003-024-06102-y. PMID: 38729981; PMCID: PMC11549098.

Moreno RJ, Ashwood P. An Update on Microbial Interventions in Autism Spectrum Disorder with Gastrointestinal Symptoms. Int J Mol Sci. 2024 Dec 5;25(23):13078. doi: 10.3390/ijms252313078. PMID: 39684788; PMCID: PMC11641496.

Moreno RJ, Azzam YW, Eng S, Rose D, Ashwood P. Altered Monocyte Populations and Activation Marker Expression in Children with Autism and Co-Occurring Gastrointestinal Symptoms. Biomolecules. 2025 Feb 1;15(2):207. doi: 10.3390/biom15020207. PMID: 40001509; PMCID: PMC11853397.

Moreno RJ, Rose DR, Tancredi DJ, Schmidt RJ, Ozonoff SJ, Ashwood P. Cord blood cytokine profiles in children later diagnosed with autism spectrum disorder: Results from the prospective MARBLES study. Brain Behav Immun. 2024 Nov;122:339-344. doi: 10.1016/j.bbi.2024.08.036. Epub 2024 Aug 18. PMID: 39163910.

Needham BD, Adame MD, Serena G, Rose DR, Preston GM, Conrad MC, Campbell AS, Donabedian DH, Fasano A, Ashwood P, Mazmanian SK. Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder. Biol Psychiatry. 2021 Mar 1;89(5):451-462. doi: 10.1016/j.biopsych.2020.09.025. Epub 2020 Oct 10. PMID: 33342544; PMCID: PMC7867605.

Qureshi F, Adams JB, Audhya T, Hahn J. Multivariate Analysis of Metabolomic and Nutritional Profiles among Children with Autism Spectrum Disorder. J Pers Med. 2022 Jun 1;12(6):923. doi: 10.3390/jpm12060923. PMID: 35743708; PMCID: PMC9224818.

Qureshi F, Hahn J. Towards the Development of a Diagnostic Test for Autism Spectrum Disorder: Big Data Meets Metabolomics. Can J Chem Eng. 2023 Jan;101(1):9-17. doi: 10.1002/cjce.24594. Epub 2022 Aug 10. PMID: 36591338; PMCID: PMC9799131.

SYNCHRONY ROUNDTABLE PUBLICATIONS

Frye RE, Nanda H, Pleasure SJ, Casanova MF, Boles RG, Lewine J, Gaitanis J, Adams JB. Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable. J Pers Med. 2023 Mar 20;13(3):557. doi: 10.3390/jpm13030557. PMID: 36983738; PMCID: PMC10052130.

Frankovich J, Nanda H, Mellins ED, Jyonouchi H, Boles RG, Walker SJ, Gaitanis J, Frye RE. Synchrony 2022: The Role of Neuroinflammation in Behavioral Exacerbations in Autism Spectrum Disorder. J Pers Med. 2023 Jul 13;13(7):1133. doi: 10.3390/jpm13071133. PMID: 37511746; PMCID: PMC10381638.

Belfort G, Nanda H, Slattery JC, Sambor J, Rodakis J, Frye RE. Synchrony 2022: Roundtable Discussion on the Pathways and the Challenges of Getting Medications FDA Approved. J Pers Med. 2023 Apr 30;13(5):779. doi: 10.3390/jpm13050779. PMID: 37240949; PMCID: PMC10222728.

Nanda H, Frye RE. Synchrony 2022: Catalyzing Research and Treatments to Benefit Individuals with Neurodevelopmental Disorders including Autism Spectrum Disorders. J Pers Med. 2023 Mar 9;13(3):490. doi: 10.3390/jpm13030490. PMID: 36983672; PMCID: PMC10053654.