John-Paul Yu MD PhD

University of Wisconsin–Madison


John-Paul Yu, MD, PhD, is an Assistant Professor, in Radiology (Neuroradiology), Psychiatry, and Biomedical Engineering. His research focuses on developing a comprehensive and multidisciplinary approach towards the neuroimaging of schizophrenia and neuropsychiatric disease.

Yu received his medical degree from the University of Illinois, Urbana-Champaign, where he also completed a PhD in Biophysics and Computational Biology.

Dr. Yu currently leads a systems neuroscience laboratory housed in the Wisconsin Institutes for Medial Research at the University of Wisconsin-Madison. His laboratory is currently aligned along three major thematic and interrelated areas of interest: (1) examining the impact of genes, the environment, and gene-environment interactions on quantitative brain microstructure in neurocognitive and neuropsychiatric illness; (2) biological validation and clinical translation of methodological innovations in diffusion weighted MRI for accurate diagnosis and tracking therapeutic outcomes in patient care, clinical trials, and patient-oriented research; and (3) development of MR and PET neuroimaging methods for the sensitive detection and characterization of microglial-driven neuroinflammation and synaptic loss in neurologic and psychiatric disease.

BRAIN Funded Projects

The gut-brain axis in ASD presenting with gut inflammation

Identifying how altered gut microbiome in IBD leads to increased risk for ASD by developing a novel human pediatric ASD/IBD microbiome model in mice.

Recent & Selected Publications

Montoro RA, Singh AP, Yu JJ. Structural and functional neuroimaging of the effects of the gut microbiome. Eur Radiol. 2022;32(6):3683-3692. doi:10.1007/s00330-021-08486-5Read abstract

Singh AP, Jain VS, Yu JJ. Diffusion radiomics for subtyping and clustering in autism spectrum disorder: A preclinical study [published online ahead of print, 2022 Dec 7]. Magn Reson Imaging. 2022;S0730-725X(22)00211-9. doi:10.1016/j.mri.2022.12.003Read abstract

Rigby MJ, Orefice NS, Lawton AJ, et al. Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology. Brain. 2022;145(2):500-516. doi:10.1093/brain/awab295Read abstract

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