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Ayan Mondal, PhD

Stanford University

Biography

Dr. Mondal is a post-doctoral research fellow in Prof Elizabeth Mellins’ laboratory at Dept of pediatrics, Stanford University. He completed my graduation in Microbiology from University of Calcutta, India, in 2017. He has studied novel virulence factors from pathogenic bacteria and the pathways they use to affect host cells and became well-trained in analysis of disease pathogenesis in mouse models and in in vitro systems, as well as neuroimmune signaling mechanisms in the gut-liver-brain axes in mouse models of a metabolic disorder (NAFLD/NASH) and military-deployment associated disorders (Gulf War syndrome.

His studies elucidated mechanisms of neuroinflammation and blood-brain barrier (BBB) dysfunction that can lead to comorbid symptoms using mouse brain histology and cultured brain endothelial cells as a simplified model of BBB. His work focuses on elucidating the mechanisms of action of novel modulators of BBB that are relevant to homeostatic maintenance of the BBB and other novel modulators that increase BBB permeability during flares of PANS. His proposed experimental strategies include transcriptomic and proteomic approaches in cell types of the CNS neurovascular unit.

BRAIN Funded Projects

Functional activities of plasma from autism on blood-brain barrier; Comparison with healthy controls and PANS

Aims of the study: Investigate the integrity of the blood brain barrier in autism vs PANS by looking at brain endothelial cells monolayer and multicellular systems.

Selected Publications

Mondal A, Bose D et al. Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis. Journal of Neuroinflammation. 2020 Dec;17(1):1-5.

Mondal A, Saha P, Chatterjee S et al. Environmental Microcystin exposure in underlying NAFLD- induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent. Toxicology 2021 Sep;461:152901.

Bose D, Saha P, Mondal A, Chatterjee S et al. Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long- Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model. Nutrients. 2020 Sep;12(9):2764.

Seth RK, Maqsood R, Mondal A et al. Gut DNA virome diversity and its association with host bacteria regulate inflammatory phenotype and neuronal immunotoxicity in experimental Gulf War illness. Viruses. 2019 Oct;11(10):968.

Mondal A. Pal et al. Cytotoxic and inflammatory responses induced by outer membrane vesicle- associated biologically active proteases from Vibrio cholerae. Infection and Immunity. 2016 May 1;84(5):1478-90.

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