Edward Quadros, PhD

SUNY Downstate


Edward Quadros, PhD, is a Research Professor at SUNY – Downstate in the Departments of Medicine and Cell Biology. His research interests include biochemical and molecular aspects of vitamin B12/folate absorption, transport and metabolism; Genetic abnormalities of vitamin B12/ folate dependent pathways; Cellular and metabolic consequences of vitamin B12 and folate deficiencies; Vitamin B12, folate and homocysteine metabolism in the elderly population with cardiovascular disease and cognitive disorders including Alzheimer’s dementia; Neuropathology of vitamin B12 and folate deficiency; B12, folate status and DNA methylation in the brain.

Another area of research actively being pursued in Dr. Quadros’ laboratory is the association of folate receptor autoimmunity with neural tube defect pregnancy and cerebral folate deficiency. Current research is focused on fetal and neonatal brain development and the role of folate and B12 in this process.

Dr. Quadros has established a strong link between an autoimmune disorder that produces autoantibodies against the folate receptor alpha, a membrane receptor involved in folate transport to the fetus and to the brain. Extensive research in Dr. Quadros’ laboratory is aimed at understanding the cause and effects of this autoimmune disorder and how best to prevent and treat the pathologic consequences.

Dr. Quadros holds a BSc in Chemistry from the University of Poona, a MSc in Applied Biology from the University of Bombay and a PhD in Biochemistry from the University of London.

BRAIN Funded Projects

Establish a Rat Model of ASD to Study Genetic & Epigenetic Changes and Associated Behavioural Deficits

Recent & Selected Publications

Bobrowski-Khoury N, Ramaekers VT, Sequeira JM, Quadros EV. Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorders: Diagnosis, Treatment and Prevention. J Pers Med. 2021;11(8):710. Published 2021 Jul 24. doi:10.3390/jpm11080710

Frye RE, Rossignol DA, Scahill L, McDougle CJ, Huberman H, Quadros EV. Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder. Semin Pediatr Neurol. 2020;35:100835. doi:10.1016/j.spen.2020.100835

Ramaekers VT, Sequeira JM, Thöny B, Quadros EV. Oxidative Stress, Folate Receptor Autoimmunity, and CSF Findings in Severe Infantile Autism. Autism Res Treat. 2020;2020:9095284. Published 2020 Nov 18. doi:10.1155/2020/9095284

Ramaekers VT, Sequeira JM, DiDuca M, et al. Improving Outcome in Infantile Autism with Folate Receptor Autoimmunity and Nutritional Derangements: A Self-Controlled Trial. Autism Res Treat. 2019;2019:7486431. Published 2019 Jun 18. doi:10.1155/2019/7486431

BRAIN Synchrony Symposia presentations

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