Harumi Jyonouchi, MD

Biography

Harumi Jyonouchi, MD, received her medical training at the Yokohama City University School of Medicine, Yokohama, Japan and then completed training in Pediatrics at Fujigaoka Hospital, Showa University, Japan. She then served as a research fellow at Sloan-Kettering Institute for Cancer Research in New York and then as a Senior Research Scientist at the Oklahoma Medical Research Foundation. She completed a fellowship in Pediatric Immunology at Oklahoma Children’s Memorial Hospital, and did additional training in Allergy/ Immunology at All Children’s Hospital, St. Petersburg, Florida, where she joined the faculty as an Assistant Professor of Pediatrics and the Assistant Director of the Immune Parameter Laboratory. She went on to become an Associate Professor of Medicine at the University of Minnesota and served as the co-director for the Allergy/ Immunology fellowship. She has been in the Department of Pediatrics at NJMS since 2002. She is the recipient of a number of honors and awards, and has served on NIH grant review committees and Editorial Boards. She is currently the Chief Editor of Pediatrics Section of eMedicine. She has had continuous grant support since 1989 and is the author of over 100 published peer- reviewed articles and chapters.

Her research interests include: neuro-immune interactions and epigenetic regulation in children with autism spectrum disorders, innate immune abnormalities in patients with mucosal inflammation of the airway (asthma) and the GI tract, and non-IgE mediated food allergy.

BRAIN Funded Projects

Biomarkers of Innate Immune Memory in Autism Spectrum Disorders

Determining the underlying mechanisms of immune mediated inflammation and their effects on the development and progress of autism.

Recent & Selected Publications

Jyonouchi H, Geng L. Associations between Monocyte and T Cell Cytokine Profiles in Autism Spectrum Disorders: Effects of Dysregulated Innate Immune Responses on Adaptive Responses to Recall Antigens in a Subset of ASD Children. Int J Mol Sci. 2019;20(19):4731. Published 2019 Sep 24. doi:10.3390/ijms20194731

Jyonouchi H, Geng L, Rose S, Bennuri SC, Frye RE. Variations in Mitochondrial Respiration Differ in IL-1ß/IL-10 Ratio Based Subgroups in Autism Spectrum Disorders. Front Psychiatry. 2019;10:71. Published 2019 Feb 20. doi:10.3389/fpsyt.2019.00071

Jyonouchi H, Geng L, Streck DL, Dermody JJ, Toruner GA. MicroRNA expression changes in association with changes in interleukin-1ß/interleukin10 ratios produced by monocytes in autism spectrum disorders: their association with neuropsychiatric symptoms and comorbid conditions (observational study). J Neuroinflammation. 2017;14(1):229. Published 2017 Nov 25. doi:10.1186/s12974-017-1003-6

BRAIN Synchrony Symposia presentations