Shannon Rose, PhD

Arkansas Children’s Research Institute


Dr. Rose is an Assistant Professor at the University of Arkansas for Medical Sciences, College of Medicine. She is actively engaged in hypothesis testing basic and translational pediatric research. Her research program utilizes novel cell biology techniques and metabolomics to study mitochondrial and redox biology in health and pediatric metabolic disorders including autism, obesity, and diabetes.

Dr. Rose’s research builds upon her predoctoral studies with Dr. S. Jill James which focused on systemic glutathione redox imbalance in autism spectrum disorder (ASD) and its association with oxidative stress and mitochondrial dysfunction. Her postdoctoral work with Dr. Richard E. Frye applied the state-of-the-art Seahorse extracellular flux technology to autism to understand the relationship between oxidative stress, environmental exposures, and mitochondrial dysfunction using immune cells from children with ASD and unaffected control children. Her studies distinguished subgroups of children with autism with atypical mitochondrial function and increased susceptibility to oxidant-induced dysfunction.

In 2020, Dr. Rose was awarded a multi-principal investigator grant from the United States-Israel Binational Science Foundation. In this study, “Transcriptomic blood biomarkers for ASD diagnostics and precision medicine prognostics,” Dr. Rose and her fellow principal investigators will use a genome-wide RNA sequencing approach to identify transcriptomic biomarkers of ASD and test transcriptomic effects of several candidate therapeutics using a lymphoblastoid cell model of ASD.

BRAIN Funded Projects

Autoantibody and Cytokine Biomarker Discovery in Patients with Autism and Neurodevelopmental Disorders

Aims of the study: Explore autoantibodies as potential inflammation markers; Measure levels of inflammatory markers in plasma in patients with neurodevelopmental disorders; Identify potential treatments including anti-inflammatory and immune-modulating therapeutics.

Selected Publications

Frye RE, Cakir J, McCarty PJ, Rose S, Delhey LM, Palmer RF, Austin C, Curtin P, Yitshak-Sade M, Arora M. Air Pollution and Maximum Temperature Are Associated with Neurodevelopmental Regressive Events in Autism Spectrum Disorder. J Pers Med. 2022 Nov 1;12(11). doi: 10.3390/jpm12111809. PubMed PMID: 36579525; PubMed Central PMCID: PMC9696106.

Brister D, Rose S, Delhey L, Tippett M, Jin Y, Gu H, Frye RE. Metabolomic Signatures of Autism Spectrum Disorder. J Pers Med. 2022 Oct 17;12(10). doi: 10.3390/jpm12101727. PubMed PMID: 36294866; PubMed Central PMCID: PMC9604590.

Voinsky I, Zoabi Y, Shomron N, Harel M, Cassuto H, Tam J, Rose S, Scheck AC, Karim MA, Frye RE, Aran A, Gurwitz D. Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder. Int J Mol Sci. 2022 Aug 30;23(17). doi: 10.3390/ijms23179843. PubMed PMID: 36077244; PubMed Central PMCID: PMC9456089.

Gill PS, Dweep H, Rose S, Wickramasinghe PJ, Vyas KK, McCullough S, Porter-Gill PA, Frye RE. Integrated microRNA-mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism. J Pers Med. 2022 Jun 1;12(6). doi: 10.3390/jpm12060920. PubMed PMID: 35743705; PubMed Central PMCID: PMC9225282.

Frye RE, Rose S, Boles RG, Rossignol DA. A Personalized Approach to Evaluating and Treating Autism Spectrum Disorder. J Pers Med. 2022 Jan 24;12(2). doi: 10.3390/jpm12020147. PubMed PMID: 35207636; PubMed Central PMCID: PMC8877244.

Frye RE, Lionnard L, Singh I, Karim MA, Chajra H, Frechet M, Kissa K, Racine V, Ammanamanchi A, McCarty PJ, Delhey L, Tippett M, Rose S, Aouacheria A. Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder. Transl Psychiatry. 2021 Oct 13;11(1):527. doi: 10.1038/s41398-021-01647-6. PubMed PMID: 34645790; PubMed Central PMCID: PMC8514530.

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