Richard Frye MD, PhD

Autism Discovery & Treatment Foundation


Richard Frye, MD Phd is a Child Neurologist with expertise in neurodevelopmental and neurometabolic disorders. He received an MD and PhD in Physiology and Biophysics from Georgetown University and completed his Child Neurology Residency and Fellowship in Behavioral Neurology and Learning Disabilities at Harvard University/ Children’s Hospital Boston.

Dr Frye has authored over 150 peer-reviewed publications and book chapters, and serves on several editorial boards. He has conducted several clinical trials demonstrating the efficacy of safe and novel treatments that target underlying physiological abnormalities in children with ASD.

He is the Chief of Neurodevelopmental Disorders at the Barrow Neurological Institute at Phoenix Children’s Hospital.

BRAIN Funded Projects

Safety and Efficacy of Transcranial Photobiomodulation (tPBM) for individuals with Autism Spectrum Disorder and Epileptiform Activity (2023)

High-Frequency Oscillation as a Biomarker of Mitochondrial Dysfunction Associated with Epilepsy in Autism (2021)

The project to deepen our understanding of the biological mechanisms that underlie epilepsy, including treatment-resistant epilepsy, and to open a path to novel biomarkers, assessment methods and treatments.

Autism with Neurodevelopmental Regression Associated Mitochondrial Dysfunction: Further Development of In Vitro Models and Pathways to Treatment (2021)

Characterizing mitochondrial dysfunction and testing agents that potentially modulate mitochondrial function in order to discover novel targeted treatments for a subset of autism.

Explore if Treatments Targeting Mitochondrial Function in Autism Will Improve the Core Symptoms (2020)

Recent & Selected Publications

Frye RE, Lionnard L, Singh I, et al. Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder. Transl Psychiatry. 2021;11(1):527. Published 2021 Oct 13. doi:10.1038/s41398-021-01647-6

Frye RE, Rose S, McCullough S, et al. MicroRNA Expression Profiles in Autism Spectrum Disorder: Role for miR-181 in Immunomodulation. J Pers Med. 2021;11(9):922. Published 2021 Sep 17. doi:10.3390/jpm11090922

Frye RE, Cakir J, Rose S, et al. Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology. Mol Psychiatry. 2021;26(5):1561-1577. doi:10.1038/s41380-020-00885-2

Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE. Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study. FASEB J. 2017;31(3):904-909. doi:10.1096/fj.201601004R

BRAIN Synchrony Symposia presentations

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