synchrony2019

the brain foundation, a 501c3 non-profit presents

synchrony 2019

International Symposium on Translational Research in Autism

Nov.8-10 Pleasanton, California

attend live or streaming

presentations

The microbiome and autism – basic research to clinical trials

Sarkis Mazmanian, PhD
Luis and Nelly Soux Professor of Microbiology, Caltech


Antipurinergic therapy to address core disabilities of ASD 

Robert Naviaux, MD, PhD

UCSD


Microbiota Transfer Therapy for Children with ASD and GI disorders: Summary of Phase 1 and Follow-Up

James Adams, PhD

Rosa Krajmalnik Brown, Ph.D.

ASU


Brain Plasticity in ASD

Michael Merzenich, PhD

Professor (Emeritus), UCSF

CSO, Posit Science Corporation

CSO, Stronger Brains


Genomic Testing in Autism Spectrum Disorder

David Bick, MD

Chief Medical Officer & Faculty Investigator,

Hudson Alpha Institute for Biotechnology


A new evidence-based method for choosing the most effective treatments for autism

Daniel Rossignol, MD, FAAFP

Rossignol Medical Center


The End ME/CFS Project

Ronald W. Davis, PhD

Professor of Biochemistry and Genetics,

Director of the Stanford Genome Technology Center

Stanford University School of Medicine


Collaborative Care in ABA Treatment for Autism 

Dennis Dixon, PhD

Chief Clinical Officer at the Center for Autism and Related Disorders (CARD)


Disruption of Brain development and function by Folate Receptor Antibodies: Treatment of Autism Spectrum Disorders

Edward Quadros, PhD

Research Professor at SUNY


Mitochondrial Medicine and Autism

Richard Boles, MD

Mitochondrial and Molecular Medicine


Seizures and Epilepsy in Autism Spectrum Disorder

Richard Frye, MD, PhD

Chief of the Division of Neurodevelopment Disorders and Director of the Autism Program at Phoenix Children’s Hospital


Autism-Associated Enterocolitis Treatment Study

Arthur Krigsman, MD

Pediatric Gastroenterologist



research days, november 8-9

Researchers will present on key topics in autism research, followed by research round tables. The round tables represent collaboration between researchers, clinicians and parent advocates to identify the multi-disciplinary research agenda required to address key issues in ASD. Attendance at the round tables is by invitation but the research talks are open to medical professionals and are free to them. To attend, register for free below.

november 8

OVERVIEW OF RESEARCH DAYS   

 8:30 – 8:35

Welcome and Introduction to Brain

Sarika Agrawal

Secretary & Board Member 

GUT-IMMUNE-BRAIN AXIS, MITOCHONDRIA & METABOLISM

8:40 – 9:20

Gut-Brain Axis in Neurologic Disorders

Sarkis Mazmanian, PhD
Luis and Nelly Soux Professor of Microbiology, Caltech


9:25 – 10:05

Mitochondria in ASD: Oxidative Stress, Toxicant Exposure, GT Metabolites & Immunity

Richard Frye, MD PhD 

Chief, Neurodevelopmental Disorders,  Phoenix Children’s Hospital; Professor of Neurology, University of Arizona 


10:10 – 10:50

Molecular Mechanisms of GI Pathology in ASD

Arthur Krigsman, MD,

Pediatric Gastroenterology Resources

Stephen Walker, PhD,

Professor, Institute for Regenerative Medicine, Wake Forest


10:55 – 11:25

Overview of BRAIN Foundation

Pramila Srinivasan, Founder & President

Gita Gupta, VP Research & Board Member

Introduction to BRAIN & BRAIN Community, Goals and Overview of  Research Days & Research Round tables 


11:30 – 12:00

Innate Immunity & Inflammatory Subtype of ASD

Harumi Jyonouchi, MD
Associate Professor, Division of Allergy, Immunology & Rheumatology, School of Medicine, Rutgers University 

12:00 PM – 1:30 PM ROUNDTABLE – ER PROTOCOLS IN ASD (BY INVITATION)

12:00 – 1:30

 LUNCH FOR ALL ATTENDEES


 1:30  – 2:10

Linking Complex ASD Phenotypes to GI Issues

Ruth Ann Luna, PhD, MB(ASCP)
Director, Medical Metagenomics, Texas Children’s Microbiome Center, Texas Children’s Hospital

PRECISION MEDICINE IN ASD 

2:15 – 2:40

Clinical Whole Genome Sequence in ASD

David Bick, MD 

CMO, Hudson Alpha Biotechnology Center 


2:45 – 3:15

Developing Interventions Through Endophenotyping & Precision Medicine in ASD

Lynn Durham, CEO, STALICLA

NEUROBEHAVIORAL EXACERBATIONS IN ASD

3:15 – 3:30

Imperative for Discussing Neurobehavioral Exacerbations in ASD

Clinician & BRAIN Community Panel


 3:30 – 4:00

Antibody Associated Encephalitis

Samuel Pleasure, MD PhD
Glenn W. Johnson, Jr. Memorial Endowed Professor

Department of Neurology, UCSF  


4:00 – 4:30

Infectious & Post-Infectious Encephalitis

Michael Wilson, MD 

Associate Professor, Neurology, UCSF Weill Institute  


 4:30 – 4:50

Microbial effects of Immunity & Role in Neurobehavioral Exacerbations

Madeline Cunningham, PhD 

George Lynn Cross Research Professor, Microbiology & Immunology, University of Oklahoma School of Medicine 


5:00

DINNER FOR ROUND TABLE ATTENDEES  (BY INVITATION) 


november 9

 8:30 – 9:00

Corticostriatal Circuit Defects in a Mouse Model of Repetitive Behaviors

Naveen Nagarajan, PhD 

Post-Doctoral Fellow, Mario Capecchi Lab

Department of Human Genetics, University of Utah 


9:05 – 9:35

Metabolic Causes of Neurobehavioral Exacerbations in ASD

Richard Frye, MD PhD  

NEUROBEHAVIORAL EXACERBATIONS IN ASD

 9:40 – 10:40

Review of Pediatric Acute Onset Neuropsychiatric Syndrome (PANS) & New Research Findings

Margo Thienemann, MD
Clinical Professor, Psychiatry & Behavioral Sciences 

Co-Director PANS Clinic, Stanford University

Jennifer Frankovich, MD 

Associate Clinical Professor, Department of Pediatrics
Allergy, Immunology Rheumatology, Stanford University

Theresa Willetts, MD PhD 

Clinical Assistant Professor, Pediatrics – Immunology & Allergy

Jill Hollenbach, PhD

Associate Professor, Neurology
UCSF Weill Institute for Neurosciences

Shamma Rahman, PhD,

Post Doctoral Fellow, Human Gene Therapy, Mellins Lab,  Stanford

MEDICAL COMORBIDITIES IN ASD 

10:45 – 11:05

Overview of Medical Comorbidities in ASD

Daniel Rossignol, MD 

Rossignol Medical Center 


11:10 – 11:25

Utility of Lumbar Picture for Investigation of Metabolic Disorders in ASD

Deborah Renaud, MD

Consultant in Neurology & Genetics, Mayo Clinic


 11:30 – 11:45

Case Study – Behavioral Improvements From Treating Comorbidities

Agnieszka Wroczyńska, MD PhD,

Medical University of Gdansk & Polish Institute of Evidence Based Medicine

TECH INNOVATIONS TO SUPPORT PRECISION MEDICINE

11:45 – 12:00

Siteless Trials

Pramila Srinivasan, PhD, CEO, Medical Mine


12:00 – 12:30 

Autism Registry & Multiomics – Ready Biobank

Richard Frye, MD PhD 

ROUND TABLES 12:45 – 5:15 (BY INVITATION)

12:45 – 2:15

Neurobehavioral Exacerbations in ASD


2:15 – 3:45

Standard of Care in ASD


3:45 – 5:15

Tech Innovations


5:30

DINNER (TICKETS AVAILABLE FOR $1000)

6 PM STARTUP SPOTLIGHT (AT  DINNER)

Antipurinergic therapy for core disabilities of ASD
Stage:
Series A Company 


Direct-to-consumer DNA tests for rare disease diagnosis

Stage: Seed  


Metabolic biomarkers for early diagnosis of ASD 

Stage: Seed 


Precision medicine & drug discovery for ASD

Stage: Series A


research round tables

*for medical professionals only


public day, november 10

8am -6pm

Listen to presentations on promising interventions that are on the path to FDA approval, as well as the state of the art in evidence-based diagnostics and care in ASD.  To attend, register below.

public day talks

8:00 – 8:30

BREAKFAST  Whether its eggs and yoghurt, or a warm bowl of Steel Cut Oatmeal topped with fresh fruit, there are a lot of great-tasting reasons to come join us for breakfast! 


8:30 – 8:40

Welcome Remarks, Pramila Srinivasan, PhD, President, The BRAIN Foundation

THEME: NEW DIRECTIONS AND CLINICAL TRIALS FOCUSED ON BETTER QUALITY OF LIFE IN ASD 

8:40 – 9:10 

Opening Presentation: Precision Medicine and its applicability to Autism 

Michael Snyder, PhD, Chair of Genomics, Stanford University


9:10 – 9:40

Sarkis Mazmanian, PhD, Luis & Nelly Soux Professor of Microbiology in the Division of Biology and Biological Engineering, CalTech  – Gut-brain axis in ASD and Axial Biotherapeutics’ gut-focused therapeutics 


9:40 – 10:10

KEYNOTE: Michael Merzenich,  PhD, Professor Emeritus in Neuroscience, UCSF &  Winner of the 2016 Kavli Prize presents  “Brain Plasticity in ASD” 


10:10 – 10:15 

ENTERTAINMENT BREAK 


10:15 – 10:45 

Lynn Durham, MSc, CEO, Stalicla Precision medicine-based therapeutics and a new candidate drug to decrease core disabilities for a subset of ASD individuals 


10:45 – 11:15

Robert Naviaux, MD, PhD, UCSDAntipurinergic therapy to address core disabilities of ASD 


11:15 – 11:20 

ENTERTAINMENT BREAK 


11:20 – 11:50 

Jim Adams, PhDMTT, ASU

THEME: EVIDENCE-BASED DIAGNOSIS AND TREATMENT OF MEDICAL COMORBIDITIES IN ASD 

11:50 – 12:20   

David Bick, MD – Clinical Genomics in ASD 


12:20 – 12:50 

KEYNOTE: Ron Davis, PhD – How we’re approaching translational research in Chronic Fatigue Syndrome (CFS/ME) 


12:50 – 1:50 

LUNCH: Mediteranean fare with fresh organic vegetables and garden herbs


1:50 – 2:20 

Dennis Dixon, PhDImproving therapy outcomes by addressing medical comorbidities 


2:20 – 2:50 

Daniel Rossignol, MD, FAAFP–  Review of evidence-based interventions, efficacy ratings and quality of evidence


2:50 – 3:50 

Richard Frye, MD, PhD, Edward Quadros, PhD, Richard Boles, MD and Madeline Cunningham, PhD Seizures, Mitochondrial, Metabolic and immunological Comorbidities in ASD, and Improving Speech with folinic acid


TURNING SCIENTISTS INTO ENTREPRENEURS 

Talk to Sean O’ Sullivan of SOSV Ventures about how his accelerator programs help transform  scientists into entrepreneurs with $250k in seed funding and a 4-month design driven program to build groundbreaking biotech companies!  

Sign ups  between 12-1:30  PM at the registration desk. 

Space is limited. 

3:50 – 4:00

ENTERTAINMENT BREAK 

MEET THE EXPERT! First 50 signups between 12-2 PM at the registration desk can meet the experts from 4:00 PM – 7:00 PM for 1:1 discussions. Space is strictly limited – absolutely NO exceptions! 

4:00 – 4:40 

Arthur Krigsman, MD, and Stephen Walker, PhD

Gastrointestinal Comorbidities in ASD 


4:40 – 5:30

BRAIN FUNDED RESEARCH UPDATESFrye, Krigsman, Ashwood and Closing Remarks


5:30 – 6:00

Raffles, prizes and volunteer recognition/plaques
Starting 6 PM, there will be refreshments for sale. 


MEET THE EXPERT 4:00 – 7:00 PM 

Meet a curated list of physicians, researchers and therapy experts in a small group  experience brought to you by BRAIN Foundation. 


If you have questions please contact us at register@brainfoundation.org

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